Evaluation of Antidepressant Activity of Ondansetron in Albino Mice

Unfortunately, it is not fully known what exactly causes clinical depression for a particular individual. There are many theories about causes such as biological and genetic factors, environmental influences. Complications with depression may include excess weight which can lead to heart disease and diabetes, family conflicts, social isolation. This study aimed at evaluating the antidepressant activity of ondansetron in albino mice. To evaluate antidepressant effect of ondansetron in 3 graded doses 0.5 mg/kg , 1.0mg/kg and 2.0 mg/kg in albino mice by comparing their effect with fluoxetine doses 10mg/kg , 20mg/kg by using physically induced depression models tail suspension test and despair swim test. Drug induced depression model was assessed by haloperidol induced catalepsy. Ondansetron treated albino mice groups with dose dependent increase of 0.5mg/kg, 1.0mg/kg & 2.0mg/kg showed significant decrease in antidepressant activity and increase in catalepsy score when compared with fluoxetine 10mg/kg and 20mg/kg. Ondansetron 2mg/kg is euipotent to 20mg/kg fluoxetine. Thus the present result indicates antidepressant effect of ondansetron in different doses against fluoxetine in animal models.